Hale Hieronymus

 

Memorial Sloan Kettering Cancer Center

1275 York Ave Box 20, New York, NY 10065

 

 

 

EXPERIENCE

 

2008 - present Senior Scientist, Memorial Sloan Kettering Cancer Center, New York, New York

Research focuses on cancer genomes and genomic alterations, their associations with cancer outcomes, as well as modeling them in organoid and animal models

2005 - 2007 Post-doctoral research fellow, Broad Institute of Harvard and MIT, Laboratory of Todd Golub, Harvard University and Massachusetts Institute of Technology

Post-doctoral research centered on nuclear hormone receptor and kinase signaling and computational approaches to signalling and drug target prediction in cancer

   

1999 - 2004 Doctoral student, Harvard University, Laboratory of Pamela Silver,  Department of Biological Chemistry and Molecular Pharmacology, Department of Systems Biology, Harvard Medical School

Ph.D. thesis focused on the RNA-protein interactions and genomics of nuclear transport of mRNA and its and integration with gene expression processes

 

1998 Undergraduate research fellow, Laboratory of Vishwanath Lingappa, UCSF

Examined the role and mechanism of apoptosis in heritable neurodegenerative prion disease.

 

 

 

EDUCATION

 

1999 - 2004 Harvard Medical School, Harvard University, Boston, MA

Ph.D. in Biological and Biomedical Sciences, 

 

1997 - 1998 Oxford University, Oxford, England

Visiting student, Department of Biochemistry, junior year

 

 

 

SELECT PUBLICATIONS

Hieronymus H, Murali R, Tin A, Abida W, Yadav KK, Moller H, Berney DM, Scher HI,Carver BS,Scardino PT, Schultz N, Scardino PT, Taylor BS , Vickers A, Cuzick J, Sawyers CL. Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death. Submitted.

Hieronymus H, Iaquinta PJ, Wongvipat J, Gopalan A, Murali R, Mao N, Carver BS, Sawyers CL. Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis. Nature Comm. 8:1081 (2017).

Liu X, Grogan TR, Hieronymus H, Cheng D, Zhang L, Huang K, Tanya Stoyanova T, Park JW, Ruzanna O. Shkhyan RO, Nowroozizadeh B,Rettig MB, Sawyers CL, Elashoff D, Horvath S, Huang J, Witte ON, Goldstein AS. Identification of progenitor-like inflammation-associated luminal cells that can initiate human prostate cancer and predict poor outcome. Cell Rep 17: 2596-2606 (2016).

 

Wanjala J, Taylor BS, Chapinski C, Hieronymus H, Wongvipat J, Chen Y, Nanjangud GJ, Schultz N, Xie Y, Liu S, Lu W, Yang Q, Sander C, Chen Z, Sawyers CL, Carver BS. Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling. Mol Cancer Ther. 14:278-88 (2015).

 

Hieronymus H, Schultz N, Gopalan A, Carver BS, Chang MT, Xiao Y, Heguy A, Huberman K, Bernstein M, Assel M, Murali R, Vickers A, Scardino P, Sander C, Reuter V, Taylor BS, and Sawyers CL. Copy number alteration burden predicts prostate cancer relapse. Proc Natl Acad Sci. doi 10.1073 (2014).

 

Polkinghorn WR, Parker JS, Lee MX, Kass EM, Spratt DE, Iaquinta PJ, Arora VK, Yen WF, Cai L, Zheng D, Carver BS, Chen Y, Watson PA, Shah NP, Fujisawa S, Goglia AG, Gopalan A, Hieronymus H, Wongvipat J, Scardino PT, Zelefsky MJ, Jasin M, Chaudhuri J, Powell SN, Sawyers CL. Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer Discov. 3(11):1245-53 (2013).

Hieronymus H, Sawyers CL. Traversing the genomic landscape of prostate cancer from diagnosis to death. Nat Genet. 44:613-4 (2012).

Yang X, Boehm JS, Yang X, Salehi-Ashtiani K, Hao T, Shen Y, Lubonja R, Thomas SR, Alkan O, Bhimdi T, Green TM, Johannessen CM, Silver SJ, Nguyen C, Murray RR, Hieronymus H, Balcha D, Fan C, Lin C, Ghamsari L, Vidal M, Hahn WC, Hill DE, Root DE. A public genome-scale lentiviral expression library of human ORFs. Nat Methods 8:659-61 (2011).

Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, Scardino PT, Rosen N, Sawyers CL Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 19, 575-86 (2011).

Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Brown K, Miller VA, Hannon G, Sawyers CL. CD95/Fas and NFκB signaling modulate dependence of lung cancers on mutant

EGFR. Nature. 471: 523-6 (2011).

Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Barretina J, Caponigro G, Cheung HW, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub TR, Dummer R, Weber B, Sellers WR, Schlegel R, Hahn WC, Garraway LA. COT/MAP3K8 drives resistance to selective B-RAF inhibition via MAPK pathway reactivation. Nature. 468: 968-72 (2010).

Taylor BS*, Schultz N*, Hieronymus H*, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, Antipin Y, Mitsiades N, Landers T, Dolgalev I, Major JE, Wilson M, Socci ND, Lash AE, Heguy A, Eastham JA, Scher HI, Reuter VE, Scardino PT, Sander C, Sawyers CL, Gerald WL. Integrative genomic profiling of human prostate cancer Cancer Cell. 18:11-22 (2010).

* contributed equally to this work

King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet. 5: 524-6 (2009).

Du J, Bernasconi P, Clauser KR, Mani DR, Finn SP, Beroukhim R, Burns M, Julian B, Peng XP, Hieronymus H, Maglathlin RL, Lewis TA, Liau LM, Nghiemphu P, Mellinghoff IK, Louis DN, Loda M, Carr SA, Kung AL, Golub TR.   Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy.   Nat Biotechnol. 27: 77-83 (2009). Epub 2008.

Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC,  Chiosis G, Golub TR.  Gene expression signature-based chemical genomic prediction identifies novel class of HSP90 pathway modulators.  Cancer Cell  10, 321-330 (2006).

Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP., Subramanian A, Ross KN, Reich M , Hieronymus H, Wei G, Armstrong S., Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR. The Connectivity Map: Using Gene-expression Signatures to Connect Small Molecules, Genes and Disease. Science 313:1929-35 (2006).

Hieronymus H, Silver PA. A systems view of mRNP biology.  Genes Dev. 18, 2845-60 (2004).

Hieronymus H, Yu MC, Silver PA. Genome-wide mRNA surveillance is coupled to mRNA export.

Genes Dev. 18, 2652-62 (2004).

Casolari JM, Brown CR, Komili S, West J, Hieronymus H, Silver PA. Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization. Cell 14, 427-39 (2004).

Hieronymus H and Silver PA. Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat Genet. 33, 155-61 (2003).

 

 

 

AWARDS AND GRANTS

 

2005                    

Damon Runyon Postdoctoral Fellowship (accepted)

Life Sciences Research Fund Postdoctoral Fellowship

American Cancer Society Postdoctoral Fellowship

NIH Kirschstein NRSA Postdoctoral Fellowship

 

2003                    

Harvard Fellowship finalist

 

1999                    

Howard Hughes Medical Institute Predoctoral Fellowship (accepted)

National Science Foundation Graduate Fellowship

Karin Ippen-Ihler Prize in Chemistry for academic excellence & service

Sigma Xi, national science and engineering honors society

Phi Beta Kappa