Hale Hieronymus
Memorial Sloan
Kettering Cancer Center
1275 York Ave Box 20, New York, NY 10065
EXPERIENCE
2008 - present Senior Scientist, Memorial Sloan Kettering Cancer Center, New York,
New York
Research focuses on cancer genomes and genomic alterations, their associations with cancer outcomes, as well as modeling them in organoid and animal models
2005 - 2007 Post-doctoral research fellow, Broad Institute of Harvard and MIT, Laboratory of
Todd Golub, Harvard University and Massachusetts Institute of Technology
Post-doctoral research
centered on nuclear hormone receptor and kinase
signaling and computational approaches to signalling and drug target prediction in cancer
1999 - 2004 Doctoral student, Harvard University, Laboratory of
Pamela Silver, Department of Biological Chemistry and Molecular
Pharmacology, Department of Systems Biology, Harvard Medical School
Ph.D.
thesis focused on the RNA-protein interactions and genomics of nuclear transport of mRNA and its and integration with gene
expression processes
1998 Undergraduate research fellow, Laboratory of Vishwanath Lingappa, UCSF
Examined the role and mechanism of apoptosis in
heritable neurodegenerative prion disease.
EDUCATION
1999 - 2004 Harvard Medical School,
Harvard University, Boston, MA
Ph.D.
in Biological and Biomedical Sciences,
1997 - 1998 Oxford University,
Oxford, England
Visiting
student, Department of Biochemistry, junior year
SELECT PUBLICATIONS
Hieronymus H, Murali R, Tin
A, Abida W, Yadav KK, Moller H, Berney DM, Scher HI,Carver BS,Scardino
PT, Schultz N, Scardino PT, Taylor BS , Vickers A, Cuzick J, Sawyers CL. Tumor copy number alteration burden is a pan-cancer prognostic
factor associated with recurrence and death. Submitted.
Hieronymus H, Iaquinta PJ, Wongvipat J, Gopalan A, Murali R, Mao N,
Carver BS, Sawyers CL. Deletion of
3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate
oncogenesis. Nature Comm.
8:1081 (2017).
Liu
X, Grogan TR, Hieronymus H, Cheng D,
Zhang L, Huang K, Tanya Stoyanova T, Park JW, Ruzanna O. Shkhyan RO, Nowroozizadeh B,Rettig MB, Sawyers CL, Elashoff
D, Horvath S, Huang J, Witte ON,
Goldstein AS. Identification of progenitor-like
inflammation-associated luminal cells that can initiate human prostate cancer
and predict poor outcome. Cell Rep
17: 2596-2606 (2016).
Wanjala
J, Taylor BS, Chapinski C, Hieronymus H, Wongvipat J, Chen Y, Nanjangud
GJ, Schultz N, Xie Y, Liu S, Lu W, Yang Q, Sander C,
Chen Z, Sawyers CL, Carver BS. Identifying actionable targets
through integrative analyses of GEM model and human prostate cancer genomic
profiling. Mol
Cancer Ther. 14:278-88 (2015).
Hieronymus
H, Schultz N, Gopalan A, Carver BS,
Chang MT, Xiao Y, Heguy A, Huberman K, Bernstein M, Assel M, Murali R, Vickers
A, Scardino P, Sander C, Reuter V, Taylor BS, and Sawyers CL. Copy number
alteration burden predicts prostate cancer relapse. Proc Natl Acad Sci. doi 10.1073 (2014).
Polkinghorn
WR, Parker JS, Lee MX, Kass EM, Spratt DE, Iaquinta
PJ, Arora VK, Yen WF, Cai L, Zheng
D, Carver BS, Chen Y, Watson PA, Shah NP, Fujisawa S, Goglia
AG, Gopalan A, Hieronymus H, Wongvipat J, Scardino PT, Zelefsky MJ, Jasin M, Chaudhuri
J, Powell SN, Sawyers CL. Androgen receptor signaling regulates DNA repair in
prostate cancers. Cancer Discov.
3(11):1245-53 (2013).
Hieronymus H, Sawyers CL.
Traversing the genomic landscape of prostate cancer from diagnosis to death.
Nat Genet. 44:613-4 (2012).
Yang X, Boehm JS, Yang X, Salehi-Ashtiani K, Hao T, Shen Y, Lubonja R, Thomas SR, Alkan O, Bhimdi T, Green TM, Johannessen CM, Silver SJ, Nguyen C, Murray RR, Hieronymus H, Balcha D, Fan C, Lin C, Ghamsari L, Vidal M, Hahn WC, Hill DE, Root DE.
A public genome-scale lentiviral expression library of human ORFs.
Nat Methods 8:659-61 (2011).
Carver
BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S,
Arora VK, Le C, Koutcher J, Scher
H, Scardino PT, Rosen N, Sawyers CL
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer.
Cancer Cell 19, 575-86 (2011).
Bivona
TG, Hieronymus H, Parker J, Chang K,
Taron M, Rosell R, Moonsamy P, Brown K, Miller VA, Hannon G, Sawyers CL. CD95/Fas and NFκB signaling
modulate dependence of lung cancers on mutant
EGFR. Nature. 471: 523-6 (2011).
Johannessen CM, Boehm JS, Kim SY, Thomas SR,
Wardwell L, Johnson LA, Emery CM, Stransky N, Barretina J, Caponigro G, Cheung
HW, Hieronymus H, Murray RR, Salehi-Ashtiani
K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S,
Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE,
Roberts TM, Golub TR, Dummer
R, Weber B, Sellers WR, Schlegel R, Hahn WC, Garraway LA. COT/MAP3K8 drives
resistance to selective B-RAF inhibition via MAPK pathway reactivation. Nature. 468: 968-72 (2010).
Taylor
BS*, Schultz N*, Hieronymus H*, Gopalan A, Xiao
Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, Antipin Y, Mitsiades N, Landers
T, Dolgalev I, Major JE, Wilson M, Socci ND, Lash AE,
Heguy A, Eastham JA, Scher HI, Reuter VE, Scardino
PT, Sander C, Sawyers CL, Gerald WL. Integrative genomic
profiling of human prostate cancer Cancer
Cell. 18:11-22 (2010).
* contributed equally to this work
King JC, Xu J, Wongvipat
J, Hieronymus H, Carver BS,
Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS,
Gerald WL, Sawyers CL. Cooperativity of TMPRSS2-ERG
with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet.
5: 524-6 (2009).
Du
J, Bernasconi P, Clauser
KR, Mani DR, Finn SP, Beroukhim R, Burns M, Julian B,
Peng XP, Hieronymus H, Maglathlin
RL, Lewis TA, Liau LM, Nghiemphu
P, Mellinghoff IK, Louis DN, Loda
M, Carr SA, Kung AL, Golub TR. Bead-based
profiling of tyrosine kinase phosphorylation
identifies SRC as a potential target for glioblastoma
therapy. Nat Biotechnol. 27: 77-83
(2009). Epub 2008.
Hieronymus
H,
Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis
G, Golub TR.
Gene expression signature-based chemical genomic prediction identifies novel
class of HSP90 pathway modulators. Cancer Cell
10, 321-330 (2006).
Lamb
J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP., Subramanian A, Ross KN,
Reich M , Hieronymus H, Wei G, Armstrong S., Haggarty
SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR.
The Connectivity Map: Using Gene-expression Signatures to Connect Small
Molecules, Genes and Disease. Science 313:1929-35 (2006).
Hieronymus
H, Silver PA. A systems
view of mRNP biology. Genes
Dev. 18, 2845-60 (2004).
Hieronymus
H,
Yu MC, Silver PA. Genome-wide mRNA surveillance is coupled to mRNA export.
Casolari JM, Brown CR, Komili
S, West J, Hieronymus H,
Silver PA. Genome-wide localization of the nuclear transport machinery couples
transcriptional status and nuclear organization. Cell 14, 427-39 (2004).
Hieronymus
H
and Silver PA. Genome-wide analysis of RNA-protein interactions illustrates
specificity of the mRNA export machinery. Nat Genet. 33, 155-61 (2003).
AWARDS AND
GRANTS
2005
Damon
Runyon Postdoctoral Fellowship (accepted)
Life
Sciences Research Fund Postdoctoral Fellowship
American
Cancer Society Postdoctoral Fellowship
NIH
Kirschstein NRSA Postdoctoral Fellowship
2003
Harvard
Fellowship finalist
1999
Howard
Hughes Medical Institute Predoctoral Fellowship
(accepted)
National
Science Foundation Graduate Fellowship
Karin
Ippen-Ihler Prize in Chemistry for academic
excellence & service
Sigma
Xi, national science and engineering honors society
Phi
Beta Kappa